Res.Dev.Disabil. Eur J Nutr 2022;61(3):1199-1207. J Inherit.Metab Dis 2008;31 Suppl 2:S219-S222. 2007;178(4 Pt 1):1398-1403. Sloan, R. S., Kastan, B., Rice, S. I., Sallee, C. W., Yuenger, N. J., Smith, B., Ward, R. A., Brier, M. E., and Golper, T. A. Lacour, B., Di Giulio, S., Chanard, J., Ciancioni, C., Haguet, M., Lebkiri, B., Basile, C., Drueke, T., Assan, R., and Funck-Brentano, J. L. Carnitine improves lipid anomalies in haemodialysis patients. Chan, Y. C., Tse, M. L., and Lau, F. L. Two cases of valproic acid poisoning treated with L-carnitine. Yet, there are a few known side effects that include agitation, insomnia and nausea. Guideri, F., Acampa, M., Hayek, Y., and Zappella, M. Effects of acetyl-L-carnitine on cardiac dysautonomia in Rett syndrome: prevention of sudden death? Milazzo, L., Menzaghi, B., Caramma, I., Nasi, M., Sangaletti, O., Cesari, M., Zanone, Poma B., Cossarizza, A., Antinori, S., and Galli, M. Effect of antioxidants on mitochondrial function in HIV-1-related lipoatrophy: a pilot study. Clinico- experimental, prospective, sequential study]. Cochrane.Database.Syst.Rev. View abstract. Fagher, B., Cederblad, G., Monti, M., Olsson, L., Rasmussen, B., and Thysell, H. Carnitine and left ventricular function in haemodialysis patients. [Infantile encephalopathy associated with the MELAS A3243G mutation. 2010;16(10):919-921. Braz.J Med.Biol.Res. 2007;52(6):1768-1774. Molyneux, R., Seymour, A. M., and Bhandari, S. Value of carnitine therapy in kidney dialysis patients and effects on cardiac function from human and animal studies. 2008;8:365. 2010;38:152-5. [Values of tandem mass spectrometry in etiologic diagnosis of cerebral developmental retardation]. View abstract. Chan, A., Paskavitz, J., Remington, R., Rasmussen, S., and Shea, T. B. Efficacy of a vitamin/nutriceutical formulation for early-stage Alzheimer's disease: a 1-year, open-label pilot study with an 16-month caregiver extension. Askarpour M, Hadi A, Symonds ME, et al. Signorelli, S. S., Fatuzzo, P., Rapisarda, F., Neri, S., Ferrante, M., Oliveri, Conti G., Fallico, R., Di, Pino L., Pennisi, G., Celotta, G., and Massimiliano, A. Effect of PLC on functional parameters and oxidative profile in type 2 diabetes-associated PAD. Brass, E. P., Hoppel, C. L., and Hiatt, W. R. Effect of intravenous L-carnitine on carnitine homeostasis and fuel metabolism during exercise in humans. J Pediatr Hematol Oncol. Yarizadh H, Shab-Bidar S, Zamani B, Vanani AN, Baharlooi H, Djafarian K. The effect of L-carnitine supplementation on exercise-induced muscle damage: A systematic review and meta-analysis of randomized clinical trials. Newer research illustrates the potential benefits of carnitines different forms, which may be used for various conditions, including heart and brain diseases (22, 23). View abstract. View abstract. Potential role of levocarnitine supplementation for treatment of chemotherapy-induced fatigue in non-anemic cancer patients. Villani, R. G., Gannon, J., Self, M., and Rich, P. A. L-Carnitine supplementation combined with aerobic training does not promote weight loss in moderately obese women. View abstract. A single-center prospective pilot study. View abstract. View abstract. View abstract. View abstract. Cai, H., Yi, W., Li, M., and et al. View abstract. San Francisco, CA 94111. View abstract. Fan, J. P., Kim, H. S., and Han, G. D. Induction of apoptosis by L-carnitine through regulation of two main pathways in Hepa1c1c 7 cells. Cochrane.Database.Syst.Rev. Jing, L., Li, W. M., Zhou, L. J., and Song, J. Effects of pre-transplant L-carnitine supplementation on primary graft dysfunction in liver transplant recipients: a pilot, randomized, placebo-controlled clinical trial. View abstract. Winter SC, Szabo-Aczel S, Curry CJR, et al. Are There Side Effects to L-Carnitine Supplementation? Helms, R. A., Mauer, E. C., Hay, W. W., Jr., Christensen, M. L., and Storm, M. C. Effect of intravenous L-carnitine on growth parameters and fat metabolism during parenteral nutrition in neonates. View abstract. Cochrane.Database.Syst.Rev. Onofrj M, Fulgente T, Melchionda D, et al. Br J Dermatol 1987;117:203-6. Wang Y, Xu Y, Zou R, et al. View abstract. View abstract. 2010;42(10):1809-1818. 1996;18(1):91-96. Zhu Y, Xue C, Ou J, Xie Z, Deng J. Penn, D., Schmidt-Sommerfeld, E., and Wolf, H. Carnitine deficiency in premature infants receiving total parenteral nutrition. Healthline Media does not provide medical advice, diagnosis, or treatment. Drugs R D 2002;3:223-31. View abstract. Minerva Cardioangiol. Cavallini G, Biagiotti G, Koverech A, Vitali G. Oral propionyl-l-carnitine and intraplaque verapamil in the therapy of advanced and resistant Peyronie's disease. Eur J Appl Physiol Occup Physiol 1996;73:434-9. View abstract. When taken by mouth: L-carnitine is likely safe when taken for up to 12 months. Pharmacokinetic comparisons of two acetyl-L-carnitine formulations in healthy Korean volunteers. Clin Nutr ESPEN 2021;46:54-59. Clin Chim Acta 1982;122:369-75. J Inherit.Metab Dis 11-19-2010; View abstract. Side Effects. Report of one case]. Van Oudheusden, L. J. and Scholte, H. R. Efficacy of carnitine in the treatment of children with attention-deficit hyperactivity disorder. In children, L-carnitine has most often been used in doses of 50-100 mg/kg by mouth daily, for up to one year. J Pharmacol Exp Ther 1999;290:1482-92. 2012;5:CD007280. View abstract. The effect of enteral carnitine administration in humans. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Carnitine deficiency during valproic acid treatment. Effect of dialysate composition on the lipid response to L-carnitine supplementation. J Vasc.Surg. Segura-Bruna, N., Rodriguez-Campello, A., Puente, V., and Roquer, J. Valproate-induced hyperammonemic encephalopathy. Am.J Hypertens. Lenzi A, Sgro P, Salacone P, et al. Guevara-Campos, J., Gonzalez-Guevara, L., Parada, Y., and Urbaez-Cano, J. Anti-human immunodeficiency virus (HIV) activitiy, safety, and pharmacokinetics of adefovir dipivoxyl (9-[2-(bis-pivaloyloxymethyl)-phosphonylmethoxyethyl]adenine) in HIV-infected patients. View abstract. Pediatrics 1998;101:E9 (abstract). Safety, tolerability and symptom outcomes associated with L-carnitine supplementation in patients with cancer, fatigue, and carnitine deficiency: a phase I/II study. An analysis of 3 multicenter studies and a bibliographic review]. View abstract. Drugs Exp Clin Res 1987;13:417-23. ALCAR might do the same, but studies haven't confirmed this [95, 96, 97]. Sweets. Laevo-acetylcarnitine (Nicetile registered) treatment of senile depression. Insomnia (unable to sleep). 7-14-2009;89(26):1858-1861. G.Ital.Cardiol. J Am.Board Fam.Med. Neuro.Endocrinol.Lett. More severe and rarer side effects are seizures and muscle weakness in people prone to heart disease [ 38 ]. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Eur J Clin Pharmacol 1998;54:503-8. 2011;18(1):18-22. L carnitine side effects, safety, danger, caution, risks. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. Clin Nutr ESPEN. Am J Kidney Dis 1998;32(2):265-272. Hum.Exp.Toxicol. 2010;45(6):762-763. Spiekerkoetter, U., Lindner, M., Santer, R., Grotzke, M., Baumgartner, M. R., Boehles, H., Das, A., Haase, C., Hennermann, J. View abstract. View abstract. View abstract. View abstract. Z., Mandalidis, D., Taxildaris, K., and Vargemezis, V. Effects of L-carnitine on oxidative stress responses in patients with renal disease. View abstract. It may not be safe to take this supplement if you have liver or kidney disease, high blood pressure, seizure disorder or diabetes. Morano, S., Mandosi, E., Fallarino, M., Gatti, A., Tiberti, C., Sensi, M., Gandini, L., Buchetti, B., Lenti, L., Jannini, E. A., and Lenzi, A. Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study. 2001;37(5):1018-1028. Derosa, G., Maffioli, P., Ferrari, I., D'Angelo, A., Fogari, E., Palumbo, I., Randazzo, S., and Cicero, A. F. Comparison between orlistat plus l-carnitine and orlistat alone on inflammation parameters in obese diabetic patients. Gecele M, Francesetti G, and Meluzzi A. Acetyl-L-carnitine in aged subjects with major depression: clinical efficacy and effects on the circadian rhythm of cortisol. Rossignol, D. A. and Frye, R. E. Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis. View abstract. A., Ghaith, O., Medhat, T., George, S. K., and Elshafey, E. M. Is there a role for oral L-carnitine therapy in anemia and cardiac dysfunction management in Egyptian patients on maintenance hemodialysis? Here are 10 nootropic supplements proven to have brain-boosting benefits. 2007;110(2 Pt 2):480-482. View abstract. . View abstract. Seattle, WA: University of Washington, Seattle;1993. View abstract. The word, "carnitine" comes from the Latin word "carnus," meaning meat, because it was first isolated from meat in 1905. View abstract. Med Sci Sports Exerc. Am.J Kidney Dis 2007;50(5):803-812. B., Karall, D., de, Klerk H., Knerr, I., Koch, H. G., Plecko, B., Roschinger, W., Schwab, K. O., Scheible, D., Wijburg, F. A., Zschocke, J., Mayatepek, E., and Wendel, U. View abstract. Medical treatment to improve sperm quality. Drugs Exp Clin Res 1994;20:169-76. Hum.Reprod. Pulmonary hypertension in beta-thalassemia major and the role of L-carnitine therapy. View abstract. Oncologist. Zhou, X., Liu, F., and Zhai, S. Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review. View abstract. One interesting observation is that ingestion of CoQ10 late in the evening might cause insomnia 15 and this may be due to increased energy levels. Rev.Neurol. Santo, S. S., Sergio, N., Luigi, D. P., Giuseppe, M., Margherita, F., Gea, O. C., Roberto, F., Gabriella, C., Giuseppe, P., and Massimiliano, A. Dig Dis 2021. Clin Drug Invest 1996;11(2):90-96. Role of L-carnitine in apnea of prematurity: a randomized, controlled trial. Riccioni, C., Sarcinella, R., Izzo, A., Palermo, G., Liguori, M., Caliumi, C., Carloni, E., Paolucci, A. M., D'andrea, P., and Pompili, S. Rehabilitative treatment in peripheral artery disease: protocol application and follow-up. 2000;22(1):73-80. Nephron 1991;57(3):306-313. Ribas, G. S., Manfredini, V., de Mari, J. F., Wayhs, C. Y., Vanzin, C. S., Biancini, G. B., Sitta, A., Deon, M., Wajner, M., and Vargas, C. R. Reduction of lipid and protein damage in patients with disorders of propionate metabolism under treatment: a possible protective role of L-carnitine supplementation. G.Ital.Nefrol. View abstract. Torrioli, M. G., Vernacotola, S., Mariotti, P., Bianchi, E., Calvani, M., De Gaetano, A., Chiurazzi, P., and Neri, G. Double-blind, placebo-controlled study of L-acetylcarnitine for the treatment of hyperactive behavior in fragile X syndrome. Wadman, R. I., Bosboom, W. M., van den Berg, L. H., Wokke, J. H., Iannaccone, S. T., and Vrancken, A. F. Drug treatment for spinal muscular atrophy types II and III. Rathod, R., Baig, M. S., Khandelwal, P. N., Kulkarni, S. G., Gade, P. R., and Siddiqui, S. Results of a single blind, randomized, placebo-controlled clinical trial to study the effect of intravenous L-carnitine supplementation on health-related quality of life in Indian patients on maintenance hemodialysis. B., Gokcay, G., Grunewald, S., Guffon, N., Maier, E. M., Morava, E., Geb, S., Schwahn, B., Walter, J. H., Wendel, U., Wijburg, F. A., Muller, E., Kolker, S., and Horster, F. Diagnostic work-up and management of patients with isolated methylmalonic acidurias in European metabolic centres. View abstract. Cardiologia 1990;35(7):591-596. 2020;151:104554. View abstract. nausea or vomiting Less common Abdominal discomfort body odor depression dizziness impaired vision loss of appetite or weight swelling in hands, lower legs, and feet tingling sensation weakness For Healthcare Professionals Applies to levocarnitine: injectable solution, oral capsule, oral solution, oral tablet.